To start off, I already had a pretty good fit, I feel like fit is something I understand well.  (r)eVolve from Rico and Gary Yamasaki got really deep into fit, and put some things in ways that tweaked my thinking a bit and mostly gave me a lot more information than I previously had.  I refit myself and as comfortable as it was before, now it feels unnaturally good.  Here is my before and after:

Previous:
4 5/16 x 4 3/8, MF - 3/8 rev, 1/8 left, RF - 3/8 rev, 5/8 right, thumb 0 any direction

New: 4 1/4 x 4 5/16, MF 5/8 rev, 3/8 left, RF - 5/8 rev, 3/8 right, thumb 1/8 fwd, 1/16 left. 

Now my hand sits on the ball even better, it's in a lot better position.  Extremely comfortable.  Like Rico has said to me, feel is everything.