I don't think that there is a right or wrong answer to this. The approach varies by bowler, bowling center, pattern being used, lane surface, who you are bowling against, etc. As such, as others have said, it's best to just be observant and see what the bowlers around you are doing. Generally speaking, if it's truly a THS, you don't have to put too much thought into it. I would just avoid the extremes. Don't come out throwing a 360-grit Crux or a 4000 highly-polished Tropical Breeze Pearl. In terms of line, I wouldn't come out trying to play 6th arrow, and I'd avoid trying to use the 1-board too. Just keep it simple.
For me, I generally start my THS league standing around 27 (I drift about 6 right) with a medium-strength ball (Zero Gravity, IQ Fusion, etc.) and play a gentle belly through the middle of the lane. This usually provides me with a little bit of hold if I'm in and decent recovery unless I throw it out the window to the right.
Now, if I'm bowling with a bunch of guys who like to go straight and burn up the track, I often move right, ball down and play there with them because staying left of them usually forces me way too deep in order to get the ball to push through the area that they're burning up. When playing those straighter lines, I prefer a ball that reads earlier and stays smooth; otherwise, the ball dives too hard at the break point, and I am in for 9-pins and/or designer splits.
On the flip side, if I'm bowling with a bunch of hi-rev guys, I generally try to jump in with them. Even though I don't rip the cover off of the ball the way some of them do, I can use the friction they're creating to give me great recovery out and more hold than they get in. For this, a hybrid like the IQ Tour Fusion works really well in most cases, though sometimes I can go up to something like the Zero Gravity or possibly ball down to the Punch Out.